Moral philosophers aside, people sustain a vital interest in the results of ethical theorizing only on the hope that these results will eventually provide satisfying, clear, and univocal answers to essential moral questions like: What is Right Action? What is Good? But whatever else might be said of this century’s labors in moral philosophy, they have failed utterly to nurture this hope. Instead, the overwhelming perception has been that this sort of answer to these questions is beyond our ken, or (...) else that the questions themselves are somehow unintelligible. It would not be unrealistic to forecast a dismal and lonely future for the discipline of ethics should this perception continue to be the dominant one. (shrink)

Moral philosophers aside, people sustain a vital interest in the results of ethical theorizing only on the hope that these results will eventually provide satisfying, clear, and univocal answers to essential moral questions like: What is Right Action? What is Good? But whatever else might be said of this century’s labors in moral philosophy, they have failed utterly to nurture this hope. Instead, the overwhelming perception has been that this sort of answer to these questions is beyond our ken, or (...) else that the questions themselves are somehow unintelligible. It would not be unrealistic to forecast a dismal and lonely future for the discipline of ethics should this perception continue to be the dominant one. (shrink)

An attempt is made to answer this question by first analyzing the structure of Darwinian inheritance as it is exemplified in the current biological theory of evolution. Based on this analysis a generalized framework for Darwinian inheritance containing conditions which must be met by all proper Darwinian evolutionary theories is developed. Subsequently this framework is employed to assess, in part, the adequacy of Toulmin's evolutionary epistemology. Although Toulmin asserts that Darwinian inheritance operates in conceptual development, the framework is used to (...) show that the structure of concepts which he presents is unable to support the requirements for this kind of inheritance. It is concluded that Toulmin's evolutionary theory is not truly Darwinian. (shrink)

The theory of evolution is supported by the theory of genetics, which provides a single causal mechanism to explain the activities of replicators and interactors. A common misrepresentation of the theory of evolution, however, is that interaction (involving interactors), and transmission (involving replicators), are distinct causal processes. Sandra Mitchell (1987) is misled by this. I discuss why only a single causal mechanism is working in evolution and why it is sufficient. Further, I argue that Mitchell's mistaken view of the causal (...) mechanism in evolution prevents her from resolving the conflict between Dawkins and Brandon. I conclude that the unit-of-selection question remains very much alive. (shrink)

The power of the application of bioinformatics across multiple publicly available transcriptomic data sets was explored. Using 19 human and mouse circadian transcriptomic data sets, we found that NR1D1 and NR1D2 which encode heme‐responsive nuclear receptors are the most rhythmic transcripts across sleep conditions and tissues suggesting that they are at the core of circadian rhythm generation. Analyzes of human transcriptomic data show that a core set of transcripts related to processes including immune function, glucocorticoid signalling, and lipid metabolism is (...) rhythmically expressed independently of the sleep‐wake cycle. We also identify key transcripts associated with transcription and translation that are disrupted by sleep manipulations, and through network analysis identify putative mechanisms underlying the adverse health outcomes associated with sleep disruption, such as diabetes and cancer. Comparative bioinformatics applied to existing and future data sets will be a powerful tool for the identification of core circadian‐ and sleep‐dependent molecules. (shrink)

Alzheimer's disease (AD) is the most common cause of dementia, and there is currently no cure. The “β‐amyloid cascade hypothesis” of AD is the basis of current understanding of AD pathogenesis and drug discovery. However, no AD models have fully validated this hypothesis. We recently developed a human stem cell culture model of AD by cultivating genetically modified human neural stem cells in a three‐dimensional (3D) cell culture system. These cells were able to recapitulate key events of AD pathology including (...) β‐amyloid plaques and neurofibrillary tangles. In this review, we will discuss the progress and current limitations of AD mouse models and human stem cell models as well as explore the breakthroughs of 3D cell culture systems. We will also share our perspective on the potential of dish models of neurodegenerative diseases for studying pathogenic cascades and therapeutic drug discovery. (shrink)

Data are lacking with regard to participants' perspectives on return of genetic research results to relatives, including after the participant's death. This paper reports descriptive results from 3,630 survey respondents: 464 participants in a pancreatic cancer biobank, 1,439 family registry participants, and 1,727 healthy individuals. Our findings indicate that most participants would feel obligated to share their results with blood relatives while alive and would want results to be shared with relatives after their death.

This volume has 41 chapters written to honor the 100th birthday of Mario Bunge. It celebrates the work of this influential Argentine/Canadian physicist and philosopher. Contributions show the value of Bunge’s science-informed philosophy and his systematic approach to philosophical problems. The chapters explore the exceptionally wide spectrum of Bunge’s contributions to: metaphysics, methodology and philosophy of science, philosophy of mathematics, philosophy of physics, philosophy of psychology, philosophy of social science, philosophy of biology, philosophy of technology, moral philosophy, social and political (...) philosophy, medical philosophy, and education. The contributors include scholars from 16 countries. Bunge combines ontological realism with epistemological fallibilism. He believes that science provides the best and most warranted knowledge of the natural and social world, and that such knowledge is the only sound basis for moral decision making and social and political reform. Bunge argues for the unity of knowledge. In his eyes, science and philosophy constitute a fruitful and necessary partnership. Readers will discover the wisdom of this approach and will gain insight into the utility of cross-disciplinary scholarship. This anthology will appeal to researchers, students, and teachers in philosophy of science, social science, and liberal education programmes. 1. Introduction Section I. An Academic Vocation Section II. Philosophy Section III. Physics and Philosophy of Physics Section IV. Cognitive Science and Philosophy of Mind Section V. Sociology and Social Theory Section VI. Ethics and Political Philosophy Section VII. Biology and Philosophy of Biology Section VIII. Mathematics Section IX. Education Section X. Varia Section XI. Bibliography. (shrink)

State Medical Boards (SMBs) can take severe disciplinary actions (e.g., license revocation or suspension) against physicians who commit egregious wrongdoing in order to protect the public. However, there is noteworthy variability in the extent to which SMBs impose severe disciplinary action. In this manuscript, we present and synthesize a subset of 11 recommendations based on findings from our team’s larger consensus-building project that identified a list of 56 policies and legal provisions SMBs can use to better protect patients from egregious (...) wrongdoing by physicians. (shrink)

Considero, para entender a parresía de Orestes, a noção de leitura diagnóstica, numa perspectiva foucaultiana do discurso, neste caso, uma leitura da política no presente. Então, toda vez que se lê, se está de certa forma também pensando no presente e estabelecendo relações com esse tempo atual, acerca de várias questões que afetam a nossa constituição, enquanto sujeitos no mundo. As perguntas feitas acerca de que parresía fala Foucault, pressupõem que há outras possiblidades de pensá-la, para mostrar como essa parresía (...) insurge hoje no campo da grande polis brasileira. Então, defendo que cabe a nós não pensarmos que estamos fazendo uma leitura apenas desse mito Orestes e de uma discussão de um conceito que é feito por Foucault, mas que estamos trazendo essa discussão para o presente com o objetivo de ampliar a discussão e reflexão de nossa atualidade. Faz-se pertinente perguntar que relação existe entre parresía e democracia? Que sentidos produzo toda vez que eu digo a verdade? Pressuponho que o mesmo se possa perguntar com relação à democracia e vice versa, é exatamente assim que acontece ou existem nuances? Se toda parresía é garantia de um Estado democrático, de que parresía trata, então, a tragédia de Orestes? É possível falar de uma má parresía? Este conjunto de questões são exatamente o que fundamenta as discussões que Foucault vai trazer a partir de Orestes. Temos, a partir desta leitura de Orestes, o Michael Foucault em seu anúncio de uma genealogia da política, o que é muito relevante para um diagnóstico da política na atualidade. PALAVRAS-CHAVE: Parresía; Estado Democrático; Orestes. (shrink)

Background: There are few standardized measures available to assess executive function in a naturalistic setting for children. The Children’s Cooking Task is a complex test that has been specifically developed to assess EF in a standardized open-ended environment. The aim of the present study was to evaluate the internal consistency, inter-rater reliability, sensitivity and specificity, and also convergent and divergent validity of the Norwegian version of CCT among children with pediatric Acquired Brain Injury and healthy controls.Methods: The present study has (...) a cross-sectional design, based on baseline data derived from a multicenter RCT. Seventy-five children with pABI from two university hospitals with parent-reported executive dysfunction and minimum of 12 months since injury/completed cancer therapy, as well as 59 HCs aged 10–17 years, were assessed with CCT using total errors as the main outcome measure. The pABI group completed tests assessing EF on the impairment level within the ICF framework, and on the participation level. In addition, they completed tests of intellectual ability, processing speed, attention, learning, and memory. Finally, overall functional outcome was evaluated for the children with pABI.Results: Acceptable internal consistency and good inter-rater reliability were found for the CCT. Children with pABI performed significantly worse on the CCT than the HCs. The CCT identified group membership, but the sensitivity and specificity were overall classified as poor. Convergent validity was demonstrated by associations between the CCT and performance-based tests assessing inhibition, cognitive flexibility, and working memory, as well as teacher-reported executive dysfunction. Divergent validity was supported by the lack of association with performance-based measures of learning and memory, attention, and verbal intellectual ability. However, there was a moderate association between the CCT and performance-based tests of processing speed. Lastly, better performance on the CCT was associated with a better functional outcome.Conclusion: Our study with a relatively large sample of children with pABI and HC’s demonstrated good psychometric properties of the CCT. CCT performance was associated with the overall level of disability and function, suggesting that CCT is related to the level of activity in everyday life and participation in society. Hence, our study suggests that the CCT has the potential to advance the assessment of EF by providing a valid analysis of real-world performance. Nevertheless, further research is needed on larger samples, focusing on predictors of task performance, and evaluating the ability of CCT to detect improvement in EF over time. The patterns of error and problem-solving strategies evaluated by the CCT could be used to inform neuropsychological rehabilitation treatmentand represent a more valid outcome measure of rehabilitation interventions. (shrink)

Child sexual exploitation and abuse has grave implications for the mental health and wellbeing of children and young people. It has been linked to a wide range of difficulties which may extend into adulthood. School-based prevention programs that aim to raise awareness are popular, however, have historically lacked robust and consistent evaluation. The purpose of the present study was therefore to explore young people’s experiences of attending a school-based theater-in-education program, and the impact this had on their awareness and understanding (...) of CSEA. Four focus groups of between four to six participants each were conducted with young people from two co-educational State schools in the United Kingdom. The approach of Template Analysis was used to analyze the data, and revealed a number of themes related to the superordinate themes of “Information and Detail Delivered” and “Format and Timing.” The results suggest that participants gained new awareness and understanding of aspects related to CSEA, including other forms of exploitation, as well as how to avoid harm and what to do “if bad things happen.” Participants further reported that the theater performance/live element of the program was particularly impactful, feeling that this was delivered to them at the right time, but suggesting that younger people would also benefit from the important messages. In addition, areas for improvement were identified in terms of the delivery of the program, and the issue of victim blaming. Findings are discussed with a view to practical implications and directions for future research. (shrink)

Some moral claims strike us as objective. It is often argued that this shows morality to be objective. Moral experience – broadly construed – is invoked as the strongest argument for moral realism, the thesis that there are moral facts or properties.See e.g. Jonathan Dancy, “Two conceptions of Moral Realism,” Proceedings of the Aristotelian Society 60 : 167–187. Realists, however, cannot appropriate the argument from moral experience. In fact, constructivists argue that to validate the ways we experience the objectivity of (...) moral claims, realism must be rejected.Christine M. Korsgaard, The Sources of Normativity . There is a general agreement that ethical theory bears the burden of proof of explaining the objective-seeming features of our moral experience.While disputing objectivity, antirealists commit themselves to account for the objectivist pretensions of moral claims. Anti-realists agree with the traditional view that moral experie .. (shrink)

A elaboração deste artigo conjunto tem por base a continuidade de um plano editorial do Grupo Kinosophia junto a Revista Inquietude, articulada a um conjunto de aulas do Prof. Früchtl, ministradas em agosto de 2011 na Faculdade de Filosofia da UFG. Sua teoria sobre filosofia do cinema contribuiu para a formação do Grupo de Estudos Kinosophia, ao promover a discussão de suas ideias no exercício de tradução de suas aulas e textos, bem como da revisão da filmografia por ele indicada. (...) Os artigos são, portanto, resultados desta experiência contada em três etapas: 1. Modernidade, subjetividade, Hegel e o Western; 2. O romantismo, o agonístico e o filme de gângster; 3. O hibridismo, Nietzsche e a ficção científica. (shrink)

Legal philosophy is a general and systematic reflection about fundamental questions regarding law. The fact that despite the efforts of contemporary jurists terms like ‘legal philosophy’, ‘legal theory’ and ‘jurisprudence’ do not have established meanings is one of the reasons behind the dispute regarding the function and validity of legal philosophy; a second issue worth considering is the transformations of law due to diverse influences such as globalization or theories on human rights. This article intends to establish common ground for (...) the discussion surrounding this issue by revisiting some of the differences between the two main western traditions, the article then proceeds to describe the general perception and evolution of jurisprudence.Resumen:La filosofía del derecho es una reflexión general y sistemática sobre las cuestiones fundamentales del derecho. El hecho de que términos como “filosofía del derecho”, “teoría del derecho” y “jurisprudencia” no tengan significados delimitados e indisputables, a pesar de los esfuerzos de los juristas contemporáneos, es una de las razones que junto con las transformaciones del derecho en virtud de la globalización y las teorías sobre derechos humanos han dado lugar a diversas disputas sobre la función y validez de la filosofía del derecho. En este artículo se pretende establecer una base común para la discusión en torno a estos problemas mediante la revisión de algunas de las diferencias que las dos principales tradiciones occidentales para después describir la precepción general y evolución de la filosofía del derecho. (shrink)

A pesquisa Os enigmas de infância e experiências em uma escola pública da cidade de Maceió/AL: o que revelam? é uma pesquisa de Mestrado, do Programa de Pós-graduação em Educação (PPGE) da Universidade Federal de Alagoas/UFAL, realizada entre 2014 e 2016. O objetivo desta, foi problematizar infância e experiências no cotidiano de uma escola pública no município de Maceió/AL de outra maneira. Para isso, usou a concepção de filosofia presente no filósofo Friedrich Nietzsche, a concepção de infância em Walter Omar (...) Kohan, de tempo em Heráclito, e de experiência nos teóricos Giorgio Agamben e Jorge Larrosa. O trabalho aqui apresentado pretende compartilhar algumas reflexões presentes na pesquisa de Mestrado mediante uma breve exposição do campus da pesquisa e dos teóricos que nos ajudaram com os enigmas infância e experiência. (shrink)

This article investigates the relation between complicity and moral responsibility.

Sabe-se que, durante alguns períodos da história, a Música e a Matemática foram ciências que compartilharam seus conceitos e discussões. Um dos períodos no qual essa comunhão se deu de maneira significativa foi o Renascimento. A Música era então classificada como ciência e, pertencendo ao grupo das matemáticas, dividia seu espaço com a Aritmética, a quem era subordinada, com a Geometria e a Astronomia. Essa divisão foi transmitida através das obras do filósofo Sevério N. Boécio e prevaleceu durante o século (...) XVI, juntamente da noção de subalternação das ciências, provida na obra de Aristóteles e de seus comentaristas. Contudo, durante a segunda metade do século XVI, o cenário teórico foi sofrendo questionamentos e sendo por vezes reformulado. Tais reformulações tomaram várias formas, todavia, foi no diálogo entre dois autores específicos, Gioseffo Zarlino (1517-1590) e Vincenzo Galilei (1533?-1591), que a estrutura vigente foi realmente abalada. Neste artigo, pretendese mostrar a relevância da subalternação das ciências na discussão metodológica para a pretendida reformulação teórica, visto que um dos problemas metodológicos centrais da demonstração nas ciências matemáticas do século XVI foi a reconciliação entre as condições ideais, que governavam o mundo matemático, no caso específico o da Aritmética, e as condições reais do mundo físico natural. It is assumed that during specific periods in history Music and Mathematics were fields which had shared concepts and topics of discussion. A very well known period in which such a communion was specific prolific was the Renaissance. Music was then a mathematic science classified within the quadrivium. During the Renaissance, this conception was well known through the works of the philosopher Boethius and the notion of the subalternate sciences was disseminated through the works of Aristotle and his commentators. However, in the sixteenth century, reformulations were demanded by a number of authors. In the works of Gioseffo Zarlino (1517-1590) and Vincenzo Galilei (1533?-1591) the question on the classification of Music and Mathematics was specifically relevant in challenging the theoretic framework. Therefore, the aim of this article is to demonstrate the relevant role of the discussion on the subalternation of sciences, as it is known that one of the central methodological problems in the demonstration of sciences during the sixteenth century was the definition and reconciliation of the abstract mathematic object and the natural object. (shrink)